Search results for "Haldane effect"
showing 6 items of 6 documents
Arterial and mixed venous blood gas status during apnoea of intubation--proof of the Christiansen-Douglas-Haldane effect in vivo.
1989
The Christiansen-Douglas-Haldane effect, in short the Haldane effect, describes the dependence of the CO2 binding of blood on the degree of oxygenation of haemoglobin. Under the physiological conditions of an ‘open’ system between blood and alveoli the partial pressure of arterial C02 (PaCO2), must be less than that of mixed venous blood (P[Formula: see text]CO2). During the unphysiological conditions of a ‘closed’ system, e.g. hyperoxic apnoea, i.e. continuous oxygen uptake without CO2 delivery by the lungs, the Paco2 will not only approximate the P[Formula: see text]CO2 but will even exceed it. Without the Haldane effect, rapid adjustment of Paco2 to P[Formula: see text]CO2 would be expe…
The Measurement of the CO2 Hb Binding Curve of Human Hemoglobin by 13C-NMR Spectrometry
1980
It is well known that under physiological conditions CO2 binds to the four terminal amino groups of hemoglobin (Hb) (Kilmartin and Rossi-Bernardi, 1971). The carbamino compounds which are formed by this reaction are involved in the Haldane effect.
Hyperoxic Intubation Apnoea: An In Vivo Model for the Proof of the Christiansen-Douglas-Haldane Effect
1989
The Christiansen-Douglas-Haldane effect (HALDANE effect) describes the different CO2 binding capacity of haemoglobin on its degree of oxygenation and was first demonstrated in vitro in 1914 (Christiansen, Douglas and Haldane, 1914).
The Interdependence of Respiratory Gas Values and pH as a Function of Base Excess in Human Blood at 37°C
1973
The accurate estimation of the transport function of human blood for respiratory gases as well as the respiratory gas exchange in human body requires detailed knowledge of the respiratory gas partial pressures and the acid-base status in the blood. Because there is an interdependence between the different respiratory gas parameters described as Bohr and Haldane effect (3,4), it is possible to obtain a general picture of the whole transport system, if these interrelations are known.
The respiratory gas values of the fetal and maternal blood in cartesian nomograms
1966
Respiratory gas values of maternal and fetal blood taken at delivery are represented in two Cartesian nomograms. They are based on data, published by vogel, fischer und thews (1965) and Fischer, Vogel und Thews (1965). The nomograms depict the interdependence of O2 pressure, O2 content, CO2 pressure and CO2 content, established by the O2 and CO2 dissociation curves, as well as by the Bohr effect and the Haldane effect. If two of the values are known, the remaining ones can be read from the nomograms.
Blood CO2 and pH Transients During Apnoea after O2 Breathing in Patients
1990
Endotracheal intubation always is combined with an apnoea the duration of which is dependent on the technique used, the skills of the intubator, and the anatomical situation. The resulting typical potential risks may be (among others) both hypoxaemia and hypercapnia. Therefore the tolerable apnoea time for an intubation procedure is limited in clinical practice to 1 – 2 minutes. It must be noted that the developing hypercapnia is inevitable, whereas hypoxaemia may be avoided even in prolonged apnoea (e.g. >2 min) with “adaequate” preoxygenation [Duda et al., 1988]. Using de-nitrogenation techniques (breathing pure oxygen for 30 to 60 min) “anaesthetized and curarized normal subjects tolerat…